Program 

March 17. 2017 – Nobel Forum, Karolinska Institutet

When What Speaker
8:30-11:00

Session I - Phenotypic Plasticity and Tumor Evolution

Chair: Bruno Amati, Italian Institute of Technology (IIT) & European Institute of Oncology (IEO)

08:30-08:50

Arrival & Registration  
08:50-09:00 Welcome Address

Anita Göndör

 09:00-09:40 Keynote lecture, "Epigenomic Stochasticity in Tumor Evolution"

Andrew P. Feinberg

Johns Hopkins University School of Medicine,
Baltimore

9:40-10:15 Alterations of the Polycomb machinery in cancers

Rafaël Margueron

Institut Curie,
Paris

10:15-10:50 Epigenetic plasticity and cancer: lessons learned from SIRT6

Raul Mostoslavsky

MGH Cancer Center, Harvard Medical School,
Boston

10:50-11:15 Coffee break
 
11:15-13:45

Session II - Transcriptional regulation and MYC

Chair: Wendy Bickmore, University of Edinburgh, IGMM

11:15-11:50 Transcriptional programs and therapeutic targets in Myc-driven tumors

Bruno Amati

Italian Institute of Technology (IIT) & European Institute of Oncology (IEO),
Milan

11:50-12:25 New perspectives on the transcriptional regulation of MYC in 3D

Rolf Ohlsson

Karolinska Institutet
Stockholm

12.25-13.45 Lunch break
 
13:45-15:55

Session III - Chromatin and genome maintenance

Chair: Terumi Kohwi-Shigematsu, UCSF, School of Dentistry, San Fransisco

13:45-14:20 Common Fragile Site replication: a race against time

Michelle Debatisse

Institut Curie, 
Paris

14:20-14:55 Genome Architecture Mapping, an orthogonal approach to map chromatin contacts

Ana Pombo

Humboldt University
Berlin

14:55-15:30 Nuclear organization in genome maintenance

Evi Soutoglou

Institut de Genetique De Biologie Moleculaire et Celluraire (IGBMC) ,
Illkirch

15:30-15:55 Coffee break
 
15:55-17:45

Session IV - Epigenetic targets in diagnosis and therapy

Chair: Maria Berdasco Menendez, Hospital Duran i Reynals, Barcelona

15:55-16:30 Epigenetic Targets in Cancer

Kristian Helin

University of Copenhagen

16:30-17:05 Identification of ligand insensitive bookmarking and architectural functions for nuclear hormone receptors in gene expression regulation

László Nagy

University of Debrecen and UD-GenoMed

17:05-17:40 Modifications of RNA in Transcription and Cancer

Tony Kouzarides

The Gurdon Institute,
University of Cambridge

17.40-17.45 Concluding remarks